Using MIMIC™ Technology to Predict Human Immune Response

The MIMIC™ system provides the benefits of both standard 2D PBMC assays and animal models, while overcoming their drawbacks. MIMIC™ technology uses human PBMCs in engineered tissue constructs that are functionally equivalent to the human immune system. The MIMIC™ system is high-throughput and cost-effective, using industry-standard 96-well microliter plates on an automated platform. The MIMIC™ system is also modular, easily accommodating variations to address different applications (e.g., vaccine and adjuvant responses, autoimmune disease).

Comparison of MIMIC™ technology with existing methods. MIMIC™ better represents the human immune response.

Attributes	Animal	PBMC	MIMIC™
Physiological environment
Uses human cells
Right vaccine introduction route
High-throughput format
Cost-effective
Captures human diversity