Immune Suppression by Dexamethasone in MIMIC® System

VaxDesign has demonstrated the ability of the Peripheral Tissue Equivalent (PTE) and Lymphoid Tissue Equivalent (LTE) modules to recapitulate the inhibitory effects of dexamethasone (Dex) on the maturation of antigen-presenting cells, the inhibition of cytokines and chemokines, and reduced T cell proliferation in the presence of the immune stimulators LPS or DTaP vaccine. Overall, it can be seen that the MIMIC® System can detect the inhibitory effect of dexamethasone on a wide range of immune responses induced by both LPS and DTaP vaccine.

Inhibitory effect of Dexamethasone on APC markers and LPS and DTaP-induced PGE2 production

Dexamethasone Reduces Th1 cytokines but increases Th2 cytokines in LTE module

Dexamethasone suppresses DTaP-induced CD4+ T cell proliferation in LTE module